XIE, Xin-hui (謝新暉)

Seeking scientific positions in academia or industry, including Assistant Professor, Postdoctoral Researcher, and Research Team Leader.

Contact Information

Main Research Interest

Identifying reliable biological markers for neuro-psychiatric disorders is a critical goal for advancing diagnosis and treatment strategies. To date, a successful example is the significance of Aβ for Alzheimer’s disease (AD). The discovery of Aβ has been significant for research on AD, whether in terms of etiology, diagnosis, or treatment.

Unfortunately, the process of finding biomarkers, especially individual-level biomarkers, for some other central nervous system (CNS) diseases has not been as successful. In my opinion, this may be due to the constraints of a basic law of signal theory—the Nyquist-Shannon sampling theorem. It requires a sampling frequency twice the highest frequency of the signal to uniquely recover the original signal.

For the discovery of Aβ: AD is a slowly progressing disease. In signal theory, any signal is a “wave”. This means that, the Aβ signal wave spans across years, and the routine frequency of sample collection (semi-annually or annually) is sufficient to capture it.

However, for rapidly changing CNS diseases (e.g., weeks or even days), daily sampling of blood or cerebrospinal fluid (CSF) from human subjects is clearly impractical. As a result, the data from routine frequency of sampling is insufficient for finding individual-level biomarkers, due to the physical limitations imposed by the Nyquist-Shannon sampling theorem.

But, A NEW HOPE is emerging.

A recent approach that enriches brain-derived extracellular vesicles (BDEVs) from peripheral blood offers direct in vivo CNS data, bypassing the blood-brain barrier, like the “New windows into the brain”.

Further, I realized that these BDEVs may also enter the urine. Therefore, I innovated a novel method for isolating BDEVs from urine (uBDEV)(Xie et al., 2024). This method allows for non-invasive and frequent, even semi-daily, collection of in vivo CNS signals, which is like taking movies instead of photos of the CNS. Hence, it has the potential to delineate intricate trajectories of CNS-specific molecular signals at the individual-level（please see figures below, the urinary astrocyte-derived EVs (uADEVs) were used as an example).

Fig. 1: Isolation and Validations of uADEVs. (A) Schematic diagram of the uADEVs isolation protocol. (B and C) NTA results of uTEVs and uADEVs. (D–G) TEM images of uTEVs and uADEVs (scale bars: 0.5 μm for D and F, 100 nm for E and G). (H) Results of western blotting: Three EV markers (CD63, CD9 and Alix) and an astrocyte marker (GFAP) were present in the ADEVs sample, while two kidney markers (NKCC2 and NCC) were absent. (I) Immunogold labeled uADEVs with anti-GLAST antibody (the back dots).

Fig. 2: The Significance of the uADEV approach. (A) The advantage of high-frequent sampling. (B) The detailed trajectories of target molecules may benefit for the exploration (Molecule A and B) and falsification (Molecule C) of pathological hypotheses. (C–E) Even under the assumption that all patients have the same molecular trajectories, yet, time-induced heterogeneity exist merely due to different sampling points along the trajectory. However, individual-level detailed trajectories may allow some post-hoc algorithms, such as peak-based realignment, to reduce the time-induced heterogeneity.

In my opinion, this method will be a game changer, and the high-frequency sampling may become a standard protocol in the field of research on rapidly changing CNS diseases.

I will obtain a Ph.D. degree in 2024. As so many questions remain in this field, I am now motivated to secure a position that will allow me to use my method and other skills to extensively explore neuro-psychiatric disorders. I am particularly interested in the following aspects of CNS diseases: uncovering new biomarkers, potentially identifying new diseases, elucidating their underlying mechanisms, developing diagnostic tools, and improving treatment strategies.

Skills

  • Study design: Full experience in trial designing and managing clinical trials, including case-control trials, cohorts, and randomized controlled trials (RCTs).

  • Leadership: Experience in leading and supervising research teams of about 5-20 members.

  • Data analyses: Experience in conducting clinical statistical analyses. Also proficient in high-throughput omics analysis, such as microbiome, proteomics, transcriptomics, and lipidomics.

Education

- Wuhan University, Wuhan, China (2021 - 2024)

  • Ph.D. candidate in Psychiatry.
  • Main research contents:
    • New methods: Innovated a method for isolating BDEVs (ADEVs, NDEVs, and oligodendrocyte-derived EVs) from urine (Xie et al., 2024).
    • BDEV, depression and electroconvulsive therapy (ECT): Investigating the status of neuroinflammation and neurogenesis in patients with major depressive disorder (MDD) using plasma/serum astrocyte-derived extracellular vesicles (ADEVs)(Xu et al., 2023) and neuro-derived EVs (NDEVs)(Xie et al., 2023), and the changes before and after ECT.
    • New rat model of depression: Inspired by the two-hit hypothesis of depression, I conceptualized a novel rat model that could offer the advantages of a stable modeling effect and can better simulate the damage to neural synapses and neurotransmitter pathways, such as GABA, observed in patients with depression.

- Anhui Medical University, Hefei, China (2011 - 2014)

  • M.S. in Psychiatry.
  • Main research contents:
    • New eye tracking algorithm for schizophrenia: designed an algorithm termed the asymmetric acceleration index (AAI) to compute the asymmetry of saccade acceleration. I found that schizophrenia patients had a significantly lower correlation coefficient (RAD) between AAI and saccade duration than healthy controls (Cui et al., 2014).

- Anhui Medical University, Hefei, China (2005 - 2010)

  • M.D. equivalent.

Professional Experience

- Brain Function and Psychosomatic Medicine Institute of Huizhou Mental Health Center (Second People’s Hospital of Huizhou), Huizhou, China

  • Scientific Consultant (Part-time (2021-Now)).
  • Director (Full-time (2017-2021)).
  • Main research contents:
    • New ECT strategy: Improved ECT with similar efficacy but reduced side effects: Hybrid-ECT (Rong et al., 2019), a pioneering approach combining efficacy of standard ECT with reduced cognitive side effects (Li et al., 2021; Zhang et al., 2022). And further evolved into i-HECT, currently in progress.
    • Schizophrenia and coronary artery calcium (CAC): Uncovered increased CAC in schizophrenia patients through COVID-19 chest CT analysis (Huang et al., 2021). Identified potential risk factors including elevated triglycerides and decreased Triiodothyronine (Huang et al., 2023).
    • Gut microbiome in mood disorders: Explored gut microbiota in patients with major depressive or bipolar disorder, highlighting distinctive microbiota patterns and links to the gut microbial tryptophan biosynthesis and metabolism pathway (MiTBamp)(Rong et al., 2019; Lai et al., 2021 a & b).
    • Additional research endeavors: Conducted a meta-analysis of MRI network topology in depression patients. (Xu et al., 2021).

- Shenzhen Mental Health Center (Shenzhen Kangning Hospital), Shenzhen, China

  • Psychiatrist (2014 - 2017, residency training program).

- Service as Reviewer

  • Schizophrenia Research.
  • Australian and New Zealand Journal of Psychiatry.
  • Human Brain Mapping.
  • Aging.
  • Scientific Reports.
  • BMC Psychiatry.
  • Frontiers in Psychiatry.
  • Others.

Publications

(Note: #First author, *Corresponding author, the selected publications were marked in bold)

  1. Xie, X. H.#*, Chen, M. M.#, Xu, S. X., Mei, J. Yang, Q., Wang, C. & Liu, Z.* (2024). Urinary Astrocyte-derived Extracellular Vesicles: A Non-invasive Tool for Capturing Human In Vivo Molecular “Movies” of Brain. medRxiv, 2024.01.12.24301104. DOI (Role: Conceptualization, Methodology, Formal analysis, Investigation, Writing - Original Draft, Writing - Review & Editing, Visualization, Supervision)

  2. Rong, J.#, Sun, S., Xu, S. X., Xie, X. H., Wang, C., Chen, G., Kang, L., Xiang, D., & Liu, Z.* (2024). The Neuroprotective Effects of BMSC-Derived Exosomes against Glutamate-Induced HT22 Cell Cytotoxicity. Neuroscience, S0306-4522(24)00039-3. PMID DOI

  3. Chen, L. C.#, Tan, W. Y.#, Xi, J. Y., Xie, X. H., Lin, H. C., Wang, S. B., Wu, G. H., Liu, Y., Gu, J., Jia, F. J.*, Du, Z. C.*, & Hao, Y. T.* (2024). Violent behavior and the network properties of psychopathological symptoms and real-life functioning in patients with schizophrenia. Frontiers in Psychiatry, 14, 1324911. DOI (Role: Conceptualization, Methodology, Validation, Writing - Review & Editing)

  4. Huang, T. Y.#, Chen, L. C.#, Li, X. P.#, Li, W. H., Xu, S. X., Nagy, C., Ibrahim, P., Nie, Z. W., Yang, N. Y., Zeng, L., Huang, H. W., Turecki, G., Xie, X. H.* (2023). Elevated Triglycerides and Low Triiodothyronine: Key Risk Factors for Coronary Artery Calcification in Schizophrenia Patients. Schizophrenia research, 264, 113-121. PMID DOI (Role: Conceptualization, Methodology, Project administration, Supervision, Writing - Review & Editing)

  5. Xie, X. H.#, Xu, S. X.#, Yao, L., Chen, M. M., Zhang, H., Wang, C.,Nagy, C., & Liu, Z.* (2023). Altered In Vivo Early Neurogenesis Traits in Patients with Depression: Evidence from Neuron-Derived Extracellular Vesicles and Electroconvulsive Therapy. Brain stimulation, 17(1), 19–28. DOI PMID (Role: Conceptualization, Formal analysis, Visualization, Writing - Original Draft)

  6. Ma, S.#, Xie, X. H., Deng, Z., Wang, W., Xiang, D., Yao, L., Kang, L., Xu, S., Wang, H., Wang, G., Yang, J.*, & Liu, Z.* (2023). A machine learning analysis of “big” metabolomics data for classifying depression: model development and validation. Biological psychiatry, S0006-3223(23)01792-4. Advance online publication. DOI PMID

  7. Zhou, E.#, Wang, W., Ma, S., Xie, X. H., Kang, L., Xu, S., Deng, Z., Gong, Q., Nie, Z., Yao, L., Bu, L.*, Wang, F.*, & Liu, Z.* (2023). Prediction of anxious depression using multimodal neuroimaging and machine learning. NeuroImage, 285, 120499. DOI PMID (Role: Writing - Review & Editing)

  8. Yao, L.#, Chen, M., Zhang, N., Ma, S., Xie, X. H., Xu, S., Nie, Z., Wang, W., Zhou, E., Xu, S., Weng, S., Chen, H., Xiang, D., & Liu, Z.* (2023). The Mediation Role of Sleep Disturbances between Vitamin D and Depressive Symptoms: A Cross-Sectional Study. Brain sciences, 13(11), 1501. DOI PMID (Role: Investigation)

  9. Xie, X. H.#*, Chen, M.M., Xu, S.X., Mei, J., Song, X.H., Liu, Z. (2023). ORAL: ISOLATING URINARY ASTROCYTE-DERIVED EXTRACELLULAR VESICLES (UADEVS): A NOVEL HIGH-FREQUENCY AND NON-INVASIVE “LIQUID-BIOPSY” APPROACH TO STUDYING CNS DISEASES. The 23rd WPA World Congress of Psychiatry. Vienna, Austria.(Role: Conceptualization, Methodology, Formal analysis, Investigation, Resources, Writing - Original Draft, Writing - Review & Editing, Visualization, Supervision)

  10. Xie, X. H.#*, Xu, S., Yao, L.H., Chen, M.M. Liu, Z. (2023). ORAL: NEUROGENESIS HYPOTHESIS OF DEPRESSION AND ELECTROCONVULSIVE THERAPY (ECT): HUMAN IN VIVO EVIDENCE FROM PLASMA NEURON-DERIVED EXTRACELLULAR VESICLES (NDEVS). The 23rd WPA World Congress of Psychiatry. Vienna, Austria. (Role: Conceptualization, Methodology, Formal analysis, Writing - Original Draft, Writing - Review & Editing, Visualization, Supervision)

  11. Mei, J.#, Song,X.#, Xie, X. H., Wang, Y. , Wang, G., Chen, C., Xu, S.X., Zhang, H., Chen, G., Liu, Z.* (2023). ORAL: MISFORTUNES NEVER COME SINGLY: A NOVEL RAT MODEL OF DEPRESSION BASED ON THEINSOMNIA-INFLAMMATION TWO-HIT HYPOTHESIS. The 23rd WPA World Congress of Psychiatry. Vienna, Austria. (Role: Conceptualization, Methodology, Formal analysis, Writing - Review & Editing, Visualization, Supervision)

  12. Xu, S. X.#, Xie, X. H.#, Yao, L., Wang, W., Zhang, H., Chen, M. M., Sun, S., Nie, Z. W., Nagy, C., & Liu, Z.* (2023). Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment-resistant depression following electroconvulsive therapy. Psychiatry and clinical neurosciences, 77, 653-664. DOI PMID (Role: Conceptualization, Formal analysis, Writing - Original Draft, Visualization)

  13. Mei, J., Wang, Y., Song, X., Xie, X. H., Wang, G., Chen, C., Chen, G., & Liu, Z.* (2023). The needle in the haystack: Identifying and validating common genes of depression, insomnia, and inflammation. Journal of affective disorders, 342, 45-53. DOI PMID (Role: Conceptualization, Methodology, Writing - Review & Editing)

  14. Xu, S. X.#, Xie, X. H.#, Yao, L., Chen, L. C., Wan, Q., Chen, Z. H., & Liu, Z.* (2023). Trajectories of Efficacy and Cognitive Function During Electroconvulsive Therapy Course in Young Adults with Treatment-Resistant Depression. Neuropsychiatric disease and treatment, 19, 267-281. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Visualization)

  15. Chen, M. M.#, Wang, P., Xie, X. H., Nie, Z., Xu, S. X., Zhang, N., Wang, W., Yao, L., & Liu, Z.* (2023). Young Adults with Major Depression Show Altered Microbiome. Neuroscience, 522, 23-32. DOI PMID

  16. Hao, K.#, Chen, F.#, Zhao, L.#, Xu, S., Xiong, Y., Xu, R., Xie, X. H., Huang, H., Shu, C., Liu, Z., Wang, H.*, & Wang, G.* (2023). Nicotinamide ameliorates mitochondria-related neuronal apoptosis and cognitive impairment via the NAD+/SIRT3 pathway. Schizophrenia (Heidelberg, Germany), 9(1), 32. DOI PMID

  17. Chen, G.#, Ma, S.#, Gong, Q.#, Xie, X. H., Wu, P., Guo, W., Kang, L., Li, M., Zhang, H., Zhou, E., Zhang, Y., Rong, J., Duan, H., Jin, L., Xu, S., Zhang, N., Sun, S., Li, R., Yao, L., Xiang, D., … Liu, Z.* (2023). Assessment of brain imaging and cognitive function in a modified rhesus monkey model of depression. Behavioural brain research, 445, 114382. DOI PMID

  18. Ma, S.#, Wang, W., Gong, Q., Xiang, D., Yao, L., Xu, S., Xie, X. H., Wang, H., Wang, G., Yang, J., & Liu, Z.* (2023). Inflammatory bowel disease and the long-term risk of depression: A prospective cohort study of the UK biobank. General hospital psychiatry, 82, 26-32. DOI PMID

  19. Nie, Z., Xie, X. H., Kang, L., Wang, W., Xu, S., Chen, M., Yao, L., Gong, Q., Zhou, E., Li, M., Wang, H., Bu, L., & Liu, Z.* (2023). A Cross-Sectional Study: Structural and Related Functional Connectivity Changes in the Brain: Stigmata of Adverse Parenting in Patients with Major Depressive Disorder? Brain sciences, 13(4), 694. DOI PMID

  20. Xie, X. H.#, Lai, W. T., Xu, S. X., Forti, M. D., Zhang, J. Y., Chen, M. M., Yao, L. H., Wang, P. L., Hao, K. K., & Han, R.* (2023). Hyper-inflammation of Astrocytes in Patients of Major Depressive Disorder: Evidence from Serum Astrocyte-derived Extracellular Vesicles. Brain, behavior, and immunity, 109, 51-62. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Writing - Original Draft)

  21. Wang, P.#, Xie, X. H., Chen, M., Zhang, N., Wang, W., Ma, S., Nie, Z., Yao, L., & Liu, Z.* (2022). Measuring childhood trauma in young adults with depression: A latent profile analysis. Asian journal of psychiatry, 80, 103387. DOI PMID

  22. Yao, L.#, Zhang, N., Ma, S., Xie, X. H., Xu, S., Xiang, D., Kang, L., Chen, M. M., Wang, P., & Liu, Z.* (2022). The relationship between vitamin D levels in seasonal variations and Chinese patients with first-episode drug-naive depression. Journal of psychosomatic research, 164, 111079. DOI PMID

  23. Hao, K.#, Wang, H.#, Zhang, Y.#, Xie, X. H., Huang, H., Chen, C., Xu, S., Xu, R., Shu, C., Liu, Z., Zhou, Y., Reynolds, G. P., & Wang, G.* (2022). Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation. Journal of neuroinflammation, 19(1), 232. DOI PMID

  24. Xu, S. X.#, Xie, X. H., Su, D., & Liu, Z.* (2022). Electroconvulsive Therapy in a Young Adult Patient With Bipolar Depression and Dysembryoplastic Neuroepithelial Tumor: A Case Report. The journal of ECT, 10.1097/YCT.0000000000000876. DOI PMID

  25. Yang, F.#, Xie, X. H.#, Li, X., Liao, H. N., & Zou, B.* (2022). Analysis of Psychological and Gut Microbiome Characteristics in Patients With Non-erosive Reflux Disease. Frontiers in psychiatry, 12, 741049. DOI PMID (Role: Methodology, Investigation, Writing - Review & Editing)

  26. Wang, Y.#, Wang, Y., Bu, L., Wang, S., Xie, X. H., Lin, F., & Xiao, Z.* (2022). Functional Connectivity Features of Resting-State Functional Magnetic Resonance Imaging May Distinguish Migraine From Tension-Type Headache. Frontiers in neuroscience, 16, 851111. DOI PMID

  27. Zhang, J. Y.#, Xu, S. X.#, Zeng, L.#, Chen, L. C., Li, J., Jiang, Z. Y., Tan, B. J., Gu, C. L., Lai, W. T., Kong, X. M., Wang, J., Rong, H., & Xie, X. H.* (2022). Improved Safety of Hybrid Electroconvulsive Therapy Compared With Standard Electroconvulsive Therapy in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Parallel-Group Pilot Trial. Frontiers in psychiatry, 13, 896018. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition)

  28. Xu, S. X.#, Deng, W. F.#, Qu, Y. Y.#, Lai, W. T., Huang, T. Y., Rong, H., & Xie, X. H.* (2021). The integrated understanding of structural and functional connectomes in depression: A multimodal meta-analysis of graph metrics. Journal of affective disorders, 295, 759-770. DOI PMID (Role: Writing - Original Draft, Writing - Review & Editing, Supervision, Project administration, Funding acquisition)

  29. Wang, J.#, Zhang, Y., Yang, Y., Liu, Z., Xia, L., Li, W., Li, Z., Xie, X. H., Deng, W., Zhang, K., & Liu, H.* (2021). The prevalence and independent influencing factors of obesity and underweight in patients with schizophrenia: a multicentre cross-sectional study. Eating and weight disorders: EWD, 26(5), 1365-1374. DOI PMID

  30. Huang, T. Y.#, Deng, W. F.#, Li, X. P., Chen, H. Q., Xu, S. X., Ke, S. H., & Xie, X. H.*(2021). Higher prevalence of coronary artery calcification in schizophrenia patients. Schizophrenia research, 231, 47-48. DOI PMID (Role: Conceptualization, Methodology, Writing - Original Draft)

  31. Li, J.#, Deng, W. F.#, Xu, S. X.#, Jiang, Z. Y., Rong, H., Kong, X. M., & Xie, X. H.* (2021). The efficacy and acceptability of hybrid electroconvulsive therapy compared with standard electroconvulsive therapy for schizophrenia patients: A parallel-group, double-blind, randomized, controlled trial. Brain stimulation, 14(3), 737-739. DOI PMID (Role: Conceptualization, Methodology, Writing - Original Draft, Writing - Review & Editing, Supervision, Funding acquisition)

  32. Lai, W. T.#, Zhao, J.#, Xu, S. X.#, Deng, W. F.#, Xu, D., Wang, M. B., He, F. S., Liu, Y. H., Guo, Y. Y., Ye, S. W., Yang, Q. F., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Liu, T. B., Tan, Z. M., Xie, X. H.*, & Rong, H.* (2021). Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients. Journal of affective disorders, 278, 311-319. DOI PMID (Role: Conceptualization, Writing - Review & Editing, Supervision, Funding acquisition)

  33. Lai, W. T.#, Deng, W. F.#, Xu, S. X.#, Zhao, J., Xu, D., Liu, Y. H., Guo, Y. Y., Wang, M. B., He, F. S., Ye, S. W., Yang, Q. F., Liu, T. B., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Xie, X. H.*, & Rong, H.* (2021). Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients. Psychological medicine, 51(1), 90-101. DOI PMID (Role: Conceptualization, Writing - Review & Editing, Supervision, Funding acquisition)

  34. 谢新晖 (Xie, X. H.)#, 陈浜#, 赵一天, 王浩, 徐淑娴, 胡衍, 荣晗, 刘江* (2020). 眼脑联动与神经精神疾病[Initiative of eye-brain joint computing in neuropsychiatric disorders]. 中华精神科杂志,053(006), 546-552. DOI

  35. Li, H.#, Zhang, S., Qian, Z. M., Xie, X. H., Luo, Y., Han, R., Hou, J., Wang, C., McMillin, S. E., Wu, S., Tian, F., Deng, W. F.*, & Lin, H.* (2020). Short-term effects of air pollution on cause-specific mental disorders in three subtropical Chinese cities. Environmental research, 191, 110214. DOI PMID

  36. Zhang, S.#, Yang, Y., Xie, X. H., Li, H., Han, R., Hou, J., Sun, J., Qian, Z. M., Wu, S., Huang, C., Howard, S. W., Tian, F., Deng, W., & Lin, H.* (2020). The effect of temperature on cause-specific mental disorders in three subtropical cities: A case-crossover study in China. Environment international, 143, 105938. DOI PMID

  37. Rong, H.#, Xu, S. X.#, Zeng, J.#, Yang, Y. J., Zhao, J., Lai, W. T., Chen, L. C., Deng, W. F., Zhang, X., Zhang, Y. L., Li, M. Z., Xiao, L., & Xie, X. H.*(2019). Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression. BMC psychiatry, 19(1), 344. DOI PMID (Role: Conceptualization, Methodology, Writing - Original Draft, Writing - Review & Editing, Supervision, Funding acquisition)

  38. Kong, X. M.#, Xie, X. H., Xu, S. X., Chen, Y., Wang, C., Hong, H., & Sun, Y.* (2019). Low-Charge Electrotherapy in Geriatric Major Depressive Disorder Patients: A Case Series. Psychiatry investigation, 16(6), 464-468. DOI PMID

  39. Rong, H.#, Xie, X. H.#, Zhao, J., Lai, W. T., Wang, M. B., Xu, D., Liu, Y. H., Guo, Y. Y., Xu, S. X., Deng, W. F., Yang, Q. F., Xiao, L., Zhang, Y. L., He, F. S., Wang, S., & Liu, T. B.* (2019). Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients. Journal of psychiatric research, 113, 90-99. DOI PMID (Role: Conceptualization, Methodology, Writing - Review & Editing, Supervision, Funding acquisition)

  40. Li, M. Z.#, Chen, L. C.#, Rong, H., Xu, S. X., Li, Y., Yang, Q. F., Deng, W. F., Yang, H. Z., Kong, X. M., Xiao, L., & Xie, X. H.*(2019). Low-charge electrotherapy for patients with schizophrenia: A double-blind, randomised controlled pilot clinical trial. Psychiatry research, 272, 676-681. DOI PMID (Role: Conceptualization, Methodology, Writing - Original Draft, Writing - Review & Editing, Supervision, Funding acquisition)

  41. Kong, X. M.#, Xu, S. X.#, Sun, Y., Wang, K. Y., Wang, C., Zhang, J., Xia, J. X., Zhang, L., Tan, B. J., & Xie, X. H.*(2017). Electroconvulsive therapy changes the regional resting state function measured by regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in elderly major depressive disorder patients: An exploratory study. Psychiatry research. Neuroimaging, 264, 13-21. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Writing - Original Draft, Writing - Review & Editing)

  42. Li, D.#, Yu, F., Ye, R., Chen, X., Xie, X. H., Zhu, C., & Wang, K.* (2017). How does gaze direction affect facial processing in social anxiety? -An ERP study. Psychiatry research, 251, 155-161. DOI PMID

  43. Zhang, J. X.#, Liu, X. H.#, Xie, X. H.*, Zhao, D., Shan, M. S., Zhang, X. L., Kong, X. M., & Cui, H.* (2015). Mindfulness-based stress reduction for chronic insomnia in adults older than 75 years: a randomized, controlled, single-blind clinical trial. Explore (New York, N.Y.), 11(3), 180-185. DOI PMID (Role: Formal analysis, Writing - Original Draft, Writing - Review & Editing)

  44. Liu, X. H.#, Xie, X. H.*, Wang, K. Y., & Cui, H.* (2014). Efficacy and acceptability of atypical antipsychotics for the treatment of post-traumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Psychiatry research, 219(3), 543-549. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Writing - Original Draft, Writing - Review & Editing, Visualization)

  45. Cui, H.#, Liu, X. H.#, Wang, K. Y., Zhu, C. Y., Wang, C., & Xie, X. H.* (2014). Association of saccade duration and saccade acceleration/deceleration asymmetry during visually guided saccade in schizophrenia patients. PloS one, e97308. DOI PMID (Role: Conceptualization, Methodology, Formal analysis, Writing - Original Draft, Writing - Review & Editing, Visualization)

  46. Liu, X.#, Cui, H.#, Wei, Q., Wang, Y., Wang, K., Wang, C., Zhu, C., & Xie, X. H.*(2014). Electroconvulsive therapy on severe obsessive-compulsive disorder comorbid depressive symptoms. Psychiatry investigation, 11(2), 210-213. DOI PMID (Role: Conceptualization, Investigation, Writing - Original Draft, Writing - Review & Editing)

  47. 谢新晖 (Xie, X. H.)#, 刘晓慧, 王晨, 朱春燕, 崔红, & 王克永* (2014). 精神分裂症患者在视觉引导眼跳中速度非对称性与眼跳幅度的相关分析. [The correlation between saccade velocity asymmetry and amplitude during visually guided saccade was lower in schizophrenia patients]. 中华精神科杂志, (5), 5. DOI

  48. Wei, Q.#, Xie, X. H.#, Chen, Y., Tian, Y., Wang, H., Wang, K., & Wang, K.* (2013). Electroconvulsive therapy and Klinefelter syndrome. The journal of ECT, 29(3), e36-e37. DOI PMID (Role: Investigation, Writing - Original Draft)